徐首红

 

徐首红  女 博士
          教授,博士生导师xushouhong@ecust.edu.cn

        1991年大学本科毕业于华东化工学院无机材料系,获学士学位;1995年赴日本名古屋市立大学药学部留学, 2001年获博士学位,2002年至2004年作为日本学术振兴会(JSPS),2004年回国至今在华东理工大学化学与分子工程学院,从事生物高分子、蛋白质等大分子的纳微米颗粒自组装结构、界面性质及其药物输送等方面的研究工作。

 

研究领域:

        生物大分子,聚电解质,两亲性大分子的有序排列、自组装和界面行为,及其在生物医药领域的应用。

 

研究方向:
        1)设计、合成智能型、功能化两亲性的大分子,研究其界面行为和自组装结构,获得多重(温度、pH、光)刺激响应型控释材料,评价作为催化剂、药物载体的应用价值。
          2)无机/有机核壳结构纳微颗粒的组装设计,研发新型、新功能的具有生物活性的组织工程修补材料和药物载体。

近期发表论文:
(1) Liu Danyang, Wang Sijia,Xu Shouhong*, Liu Honglai, Photo-controllable intermittent release of doxorubicin hydrochloride from liposomes embedded by azobenzene-contained glycolipid, Langmuir, 2017, 33, 1004~1012.
(2) Wang Sijia, Han Xia, Liu Danyang, Li Mengya, Xu Shouhong*, Liu Honglai*, Melting behavior of zipper-structuredlipopeptides in lipid bilayer, Langmuir, 2017, 33,1478~1485.
(3) Hao Weiju, Shen Yinxing, Liu Danyang, Shang Yazhuo, Zhang Junqi, Xu Shouhong*, Liu Honglai, Dual-pH-sensitivity and tumour targeting core–shell particles for intracellular drug delivery, Rsc Advances, 2017, 7(1): 851~860.
(4) Xia Tian, Hao Weiju, Shang Yazhuo, Xu Shouhong*, Liu Honglai, Incorporation of amphipathic di-block copolymer in lipid bilayer for improving pH responsiveness, International Journal of Polymer Science, Accepted, 2017.
(5) Wang Sijia, Shen Yinxing, Zhang Junqi, Xu Shouhong*, Liu Honglai, A designed lipopeptide with a leucine zipper as an imbedded on/off switch for lipid bilayer, Physical Chemistry Chemical Physics, 2016, 18: 10129~10137.
(6) Hao Weiju, Liu Danyang, Shang Yazhuo, Zhang Junqi, Xu Shouhong*, Liu Honglai, pH-Triggered copolymer micelles as drug nanocarriers for intracellular delivery, RSC Advances, 2016, 6(35): 29149~29158.
(7) Hao Weiju, Xia Tian, Shang Yazhuo, Xu Shouhong*, Liu Honglai, Characterization and release kinetics of liposomes inserted by pH-responsive bola-polymer, Colloid polymer science A, 2016, 294(7): 1107~1116.
(8) Liu Danyang, Zhang Junqi, Xu Shouhong*, Liu Honglai, Membrane property and biofunction of phospholiposome incorporated with anomeric galactolipids, Springerplus, 2016, 5: 655~666.
(9) Hao Weiju, Shang Yazhuo, Xu Shouhong*, Liu Honglai, Characterization of liposome containing bola-type copolymer and its pH controllable drug release, Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12(2): 489~490.
(10) Hao Weiju, Han Xia, Shang Yazhuo, Xu Shouhong*, Liu Honglai, Insertion of pH-sensitive bola-type copolymer into liposome as a stability anchor for control of drug release, Colloids and Surfaces B, 2015, 136(1): 809~816.
(11) Li Xiangye, Zhi Dongyan, Hu Jun, Xu Shouhong*, Liu Honglai, Synthesis of mesoporous silica-gel core-shell structural microparticles and their multiple drug delivery, Drug delivery, 2015, 22(1): 69~78.
(12) Li Xiangye, Chen Ruting, Xu Shouhong*, Liu Honglai, Thermoresponsive behavior and rheology of SiO2–hyaluronic acid/poly(N-isopropylacrylamide) (NaHA/PNIPAm) core–shell structured microparticles, Journal of Chemical Technology and Biotechnology, 2015, 90: 407~414.
(13) Liu Danyang, Wang Wanluo, He Xiao-Peng, Chen Guo-Rong, Xu Shouhong*, Liu Honglai, Anomerism differentiates the interfacial property of galactolipid-doped phospholipid monolayers, Issues in Biological Sciences and Pharmaceutical Research, 2015, 3(8):78~85.
(14) Zhi Dongyan, Li Xiangye, Xu Shouhong*, Liu Honglai, Synthesis and characterization of SiO2-gel microparticles as injectable implant biomaterials, Research on Chemical Intermediates, 2014, 40(1): 11~22.
(15) Li Xiangye, Lian Cheng, Zhi Dongyan, Xu Shouhong*, Liu Honglai, Synthesis and Swelling Behavior of SiO2-HA/PNIPAm Core-shell Structured thermoresponsive Microgels, Acta Chimica Sinica, 2014, (6): 689~696.

专利号: 201110147125.3,徐首红,蔺肖肖,李成亮,翟春涛,刘洪来:温敏性核壳型囊泡控释药物载体、其制备方法及应用(已授权)
专利号:201310046158.8,徐首红,李相晔,刘欢,李成亮,刘洪来:TiO2-HA核壳结构防晒颗粒、其制备方法及应用(已授权)
专利号:201410820848.9,徐首红,李炜,王斯佳,刘洪来:温度敏感性脂肽、含该脂肽的脂质体及其应用